Antioxidant system state in cows sick on ketosis

I. M. Petruh, M. R. Simonov, V. V. Vlizlo

In sick on ketosis highly productive cows, perioxidation processes intensify, that leads to increase of hydroperoxides in blood serum, of lipid hydroperoxides, diene conjugates and products, reactive with thiobarbituric acid. Excessive activation of lipid peroxidation processes leads to violation of membranes structure, lipid metabolism, to strengthening of lysis, to oxidization of sulfhydryl group albumens and is instrumental in accumulation of toxic products in tissues. Activation of oxidizing process in sick on ketosis cows leads to the decline of activity of superoxidedismutase and glutathione peroxidase - key enzymes of antioxidant defense. Together with the decline of antioxidant system activity at ketosis in cows structure and functions of liver is violated, that causes the increase of activity of indicator enzymes (AST, ALT) in the blood serum.

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