Influence of single chain DNA fragments of lymantria dispar nucleopolyhedrovirus on viability of gypsy moth caterpillars

V. V. Oberemok

It is shown that the external and internal use of short single chain DNA fragments of Lymantria dispar Nucleopolyhedrovirus is correlated with the increase of death rate of gypsy moth caterpillars. The similar dynamics of death rate of gypsy moth caterpillars in experimental groups from different egg masses specifies on existence of the unique mechanism of reaction on DNA fragments of virus in the individuals of insect. DNA-fragments of virus displace the biochemical reactions of host's cell toward apoptosis and in our opinion basic role in this phenomenon plays DNA-interference or process similar to it. DNA-interference with participation of DNA fragments of virus blocks the synthesis of antiapoptosis proteins, which results in apoptosis of separate cells, and in a number of cases in death of organism. Short single chain fragments of virus antiapoptosis gene are the DNA-markers of existence possibility of DNA-interference in the system of mutual relations between virus and host . Such action of DNA fragments of virus can be used for creation of fast-acting insecticides on a base of DNA.

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