Screening of microbial origin substance having antiviral activity in vitro
T. O. Bova
The results of research of anti-virus activity of microbial origin substances in vitro are presented in this article. All substances under test reduced reproduction of teshovirus in continuous line of embrionted pig kidney cell culture. However, -glucan and rhamnolipid showed the greatest anti-virus activity in concentrations only 5 times exceeding toxic ones for the culture of cells. Glucuronoksidomanan and biocomplex of pseudomonades reduced reproduction of teshovirus in vitro in concentrations 10 times exceeding ÑD50. Zymic manan and tregalozolipid turned out to be perspective for further research. Their maximal anti-virus activity was observed in 20 and more times less toxic concentrations than for EPK cell culture.
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