Immune organs changes in rats during subchronic lead and cadmium intoxication

N. N. Dmytrukha

The results of researches of lead acetate and cadmium sulphate effects (under prolonged introduction in a dose 1/100 LD50) on immune organs of white rats are presented in the article. It was established that lead cations caused inhibition of erythropoesis in bone marrow, increase of follicles number in spleen and its B-zone area, increase of follicles with the light centers of reproduction in the mesenteric lymph nodes, stimulated spleen lymphocytes proliferation to ConA and LPS. Cadmium cations caused the increase of thymus cortex, enhancement of follicles with the light centers of reproduction in the mesenteric lymph nodes, stimulated spontaneous spleen lymphocytes proliferation and reduced their answer to PHA, ConA and LPS.

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