Effect of precursors and modulator of ubiquinone (COQ) biosynthesis on activity of oxydoreductase system of mitochondrial electron-transport chain and pro- and antioxidant status in liver of old rats

O. Kuchmenko, D. Petukhov, I. Yevstratova, L. Mkhitaryan, G. Donchenko

It is shown in the article that during ageing coenzyme Q amount and activity of enzymatic complexes of mitochondrial electron-transport chain decreased in tissues of liver. We also observed activation of free radical peroxidation of lipids and proteins and inhibition of catalase activity. Injection of complex of biologically active substances that are precursors and modulator of coenzyme Q biosynthesis, which consists of ?-tocopherol acetate, 4-hydroxybenzoic acid and methionine, leads to correction of age-related changes in coenzyme Q content, functioning of mitochondrial electron-transport chain enzyme systems, intensiveness of lipid and protein free-radical peroxidation in liver tissues. The complex may be recommended for prevention of misbalancing of bio-energetic processes and intensification of lipid and protein peroxidation processes that occur during ageing.

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