Correction of lipid peroxidation in the rats large intestine mucous membrane at the combined action of vitamins C and E at stress

N. R. Shamro, I. B. Hryuk, O. Ya. Sklyarov

In the experiments on white rats, it was shown that under conditions of stress caused by injection of adrenaline there occurred enhancement of lipid peroxidation processes, increase of nitrogen oxide content and enhancement of SOD activity. Independent action of vitamin E and vitamin C resulted in reduction of lipid peroxidation processes and decrease of NO content in the MMLI, at that, effect of vitamin C was more pronounced. Single-dose injection of vitamin E at the background of stress led to insignificant changes of the content of TBA products, decrease of NO content, and reduction of SOD activity in the MMLI. Single-dose injection of vitamin C at the background of stress had a noticeable antioxidant effect, at that, lipoperoxidation processes diminished due to decrease of the content of TBA products, activity of SOD enhanced, and content of NO decreased. Combined action of vitamin E with vitamin C failed to cause inhibition of liperoxidation processes and decrease of NO content in the MMLI, and effect of vitamin E was predominant.

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