Effect of vitamin D3 and composition of vitamins on development of oxidative stress and lipid disbalance in brain tissues of rats at experimental autoimmune encephalomyelitis

E. P. Pasichna, G. V. Donchenko, R. P. Morozova

Vitamin D3 and composition of vitamins effect on development of oxidative stress and lipids metabolism disfunction, specifically on content of free SH-groups and TBA-active products, glutathionperoxidase and catalase activity in brain as well as cholesterol, sphingomyelin, ceramide and free sphingosine content in brain and glia cells of rats at experimental allergic encephalomyelitis (EAE) were studied. It was found, that vitamin D3 was facilitating in free SH-groups content rising in brain of sick animals with symptoms presence, positively influenced on condition of brain lipid peroxide oxidation (TBA-active products content was reliably reduced) and antioxidant system. Herewith sphingosine content and molar ratio cholesterol/sphingomyelin in brain tissue as well as ceramide in glial brain cells fraction of sick animals were veraciously reducing. The obtained data are indicative of positive effect of vitamin D3 on functioning glutathione system, sphingomyelin cycle, oxidative and antioxidant process activity in brain at EAE.

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