OXYGEN ACTIVE FORMS THAT THEIR ROLE IN CELLS METABOLISM

M. Kolisnyk, H. Colisnic, J. Niedziolka, V. Vlizlo

Generalized modern literary data concerning basic ways of active oxygen forms formation in the organism of animals and their role at transduction of regulatory signals in the cell and activating of free radical processes are given in this article. The active forms of oxygen can appear in the process of electrons transfer in respiratory chain of mitohondrion, in the reactions which are catalised by oxidase, at microsom and non-enzyme oxidation of substanses (haemoglobin, adrenalin etc.) at presence of ions of metals with variable valency. Intensification of formation of oxygen active forms leads to lipid peroxidation activation and oxidizing modification of albumens, nucleic acids and carbohydrates. The basic machineries of oxidizing modification of lipids and albumens which are induced by the promoted concentrations of active forms of oxygen are considered in this article.

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