Ñellular prion and their role in cell functions
V. V. Vlizlo, V. V. Stadnyk, Ch. Ya. Mayor, P. I. Verbitskii
In work was analyzed and generalized data of modern literature about cellular prion functions in cell and organisms of mammals. The analyzes of partner proteins of celluler prion carried out and indicated, that prion, as membrane protein of outer layer of plasmatic membrane, can not interacte with proteins of cytoplasm for which was demonstrated the interaction with prion in vitro.
It was shown, that prion can regulate many important physiological processes, namely apoptosis, reaction of cell to oxidative stress, interaction between cells, copper metabolism, activity of signal transduction pathways etc. But the main role of cellular prion in vivo has not been established.
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