Effect of phenylhydrazine on hypertonic sensitivity of pre-dehydrated mammalian erythrocytes

Shpakova N. M., Alexandrova D. I., Oliynik O. O., Bondarenko V. A.

The effects of phenylhydrazine (PH) modifier of cytoskeleton-membrane complex and the media of preliminary dehydration on sensitivity of mammalian erythrocytes were investigated. It has been shown that the man and horse erythrocytes are maximally steady to hypertensive shock in 4,0 M NaCl after pre-incubation in solution, containing 0,4 M, rat erythrocytes - 0,3 M, bovine erythrocytes - 1,0 M, while forming of the metastable state of man, rat, horse erythrocytes is observed during pre-incubation in an environment, containing 0,6 M NaCl and bovine erythrocytes - in 2,0 M NaCl. The joint effect of PH and dehydration medium is accompanied with level increasing and relative rate of hypertonic hemolysis of mammalian erythrocytes.

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