Redox processes in organs and tissues of mice under the feeding of brain

V. V. Vlizlo, D. D. Ostapiv, A. Z. Pylypets, I. M. Petruch, A. O. Kulbachna

The addition to the mice ratio of the cattle brain - the tissue of high risk concerning to bovine spongiform encephalopathy, inhibits the respiratory activity of mitochondria, the synthesis of ATP and the increase of oxidative processes in organism. The animal tissue caused the increase of superoxide dismutase activity and the content of prion-protein in the mice brain and decrease of these indices in spleen and intestine. The diminution of SOD activity and the prion-protein content stimulates the processes of free radical oxidation of tissue structures and may be a precondition for development of neurodegenerative processes.

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