The influence of ivermectin on the change of the enzymatic activity NA+, K+-pump of loach embryos

S.M. Mandzynets, M.V. Tselevych, D. V. Yanovich, D.I. Sanahurski.

The effect of ivermectin on the activity of Na+, K+-ATPase of the loach embryos (Misqurnus fossilis L.) during early development was been researched. It was shown that inhibit of enzyme activity is dependent of dosage the drug and the stage of embryogenesis. The inhibitory effect was evaluated in inhibition coefficient (І0,5). The value of the inhibition coefficient and analysis of the responsivity ion transport system to act of avermectin were shown higher inhibition influence of ivermectin on last stage of embryos development.

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