The influence glycosaminoglycans treatment on expression of physiological prion protein in brain of mammals

V. V. Stadnyk

The work showed, that some glycosaminoglycans, in particular, pentosan polisulfate (SP-54) and heparin are able to inhibit the general level of expression of physiologycal priona in vivo.

It was also set that given preparations specifically influence on the expression of isoforms type physiological prion, and that this influencing depends on the type of preparation, his dose, and tissue in which the proper changes are detecting.

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