Regulation of iron homeostasis in animals

R. P. Maslyanko, L. Ya. Pukalo

The absorption of iron accurately regulates the balance of iron in animals. There are three iron absorption regulators in the animal organism and they are the alimentary regulator, store regulator and erythroid regulator. The enterocytes are highly specialized cells of the duodental epithelium, which coordinate the iron uptake and its transport into the body. The survey has been focused on proteins and regulation mechanism functioning in the enterocytes heme ferrous and ferric iron in a soluble and non-toxic form it took in the process of evolution. Iron is delivered to a majority of cells after the binding of transferrin with the transferrin receptor on the cell membrane. The delivery and storing of iron in the cell is regulated post-transcriptionally by cytoplasmic factors and iron-regulation proteins (and 2 (JPR-1 and JPR-2).

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